Chemical Injury Information Network

A support and advocacy organization for people with Multiple Chemical Sensitivities (MCS) and those that care for them.

Run by the chemically injured for the benefit of the chemically injured and focuses primarily on education, credible research into MCS and the empowerment of the chemically injured.

Become a member and receive our monthly newsletter plus much more...

Become a member

Resources and Library Materials

Due to copyright and/or tax considerations, you must be a member of CIIN before ordering materials.

TO ORDER: Send appropriate funds and order numbers to:

CIIN, PO Box 301, White Sulphur Springs, MT 59645

POSTAGE: No additional postage is needed for shipping within the US unless priority handling is requested. For US Priority Mail add $7.00 for 1-75 pages.

OUTSIDE THE US add $1.50 for every 25 pages. For Global Priority Mail add $15 for 1-50 pages or $30 for 51-150 pages.

General Resources


Our Toxic Times

(back issues)

Add $1/copy for orders to Canada or Mexico; add $2/copy for orders to all other countries. (Unless otherwise specified, the most recent past issue(s) will be sent).

Environmental Directory

Contains over 200 MCS support groups and related environmental groups. $5.00

Non-Toxic Buying Guide

Lists products ranging form less-toxic construction materials to personal hygiene products. Over 200 suppliers. $7.50

CIIN Membership Directory

Upon request, a list of CIIN members in your state will be provided at no cost. For a copy of another state's members, please send $2.00 for the first state and $1.50 for each additional state.

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Introductory Medical Booklets


These booklets contain articles, patient advisories, and medical studies. They are designed to provide a basic understanding of these complex conditions for doctors, family or friends.

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MCS & the Government


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MCS General


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Rebuttals to MCS as Psychological


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Neurotoxicity


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Neurogenic Inflammation


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Time-Dependent Sensitization


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Olfaction


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Respiratory Disorders


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Immunotoxicity


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Porphyrias


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Exposure Levels


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Pesticides


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P450 Enzyme System


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Chronic Fatigue Syndrome


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Silicone Implants


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Gulf War Syndrome


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Miscellaneous


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In-House Library Services


To obtain a list of studies and articles from CIIN's in-house library, you may select from the topics listed below. CIIN will then mail you the list of studies it has on the topic(s) selected. Unfortunately because of space, a complete list of topics (over 1,000) could not be listed. So even if you don't see a topic, CIIN may still have information available. Only 5 topic lists will be provided at no charge; thereafter please include $1 per topic requested.

General Topics

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Chemicals

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Legal Information Packages


The Chemical Injury Information Network (CIIN) is building a library of legal documents and federal government recognition documents to aid chemically injured people with chemical sensitivities in their legal efforts for recognition, accommodation, and fair compensation. Some Packs include medical studies (see individual Pack descriptions). When medical studies are included, they are studies that have been published in well-established peer-reviewed medical journals. Unless otherwise noted, these information packs are set up so the documents do not overlap from one pack to the next. If the packs contain documents that are also listed in the Environmental Access Profiles: List of Back Issues, then those profile documents are noted in the description by their profile number abbreviated as "P." (Full profile listings are in the Environmental Access Profiles).

AMERICANS WITH DISABILITIES ACT:

US FEDERAL AGENCIES RECOGNITION:

US SOCIAL SECURITY DISABILITY:

US FAIR HOUSING ACT:

WORKERS' COMPENSATION:

WORKERS' COMPENSATION MEDICAL TREATMENT COVERAGE:

STATE GOVERNMENT AGENCIES RECOGNITION:

LOCAL AUTHORITIES RECOGNITION:

ENVIRONMENTAL TOBACCO SMOKE ACCOMMODATION:

SCHOOL ACCOMMODATION:

HOSPITALS AND MEDICAL FACILITIES ACCOMMODATION:

PERFUME TOXICITY:

FORMALDEHYDE SENSITIVITY:

OBJECTIVE EVIDENCE OF INJURY:

COUNTERACTING PSYCHOLOGICAL CLAIMS AS ETIOLOGY FOR MCS:

ABBA TERR:

INADEQUATE EXPOSURE STANDARDS:

DURSBAN LITIGATION:

PESTICIDE SECRET "INERT" INGREDIENTS PACK:

CARPET TOXICITY:

COUNTERACTING RONALD E. GOTS:

DAUBERT AND ADMISSIBILITY OF CLINICAL EVIDENCE PACK:

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Environmental Access Profiles


by Cindy Duehring (as of October 1999)

Back issues of Environmental Access Profiles are available only through the Chemical Injury Information Network (CIIN). The profiles are referenced and summarize the studies and highlight the main quotes for both professionals and lay people. These profiles and studies have helped numerous individuals with physician, family, and government education; workers' compensation suits and accommodation claims; Social Security disability hearings and toxic tort cases. Unless otherwise noted, all the articles profiled are from peer-reviewed journals and toxicology books. Photocopies of the actual articles may also be ordered. All orders must be prepaid. Prices listed include shipping. Duplicate profiles may be ordered, but due to copyright law, only one copy of each article may be provided per person. CIIN provides research services only and does not endorse/promote the therapies that may be mentioned in a review.

DISCOUNT

When ordering both the profile and study articles together, please take a 10% discount.

JOHNS HOPKINS PRELIMINARY MULTIPLE CHEMICAL SENSITIVITY (MCS) DATA AVAILABLE

This profile covers two papers (one published and one pre-sented at an Association of Occupational and Environmental Clinics workshop) by Linda L. Davidoff, Ph.D., a clinical psychologist at Johns Hopkins University. MCS patients do not really fit the criteria to be labeled as having a disease of psychological origin. She lists and examines the studies which have claimed that MCS is of psychological origin and finds them to be seriously flawed. Dr. Davidoff also warns that real physiological symptoms are scored as psychological in typical psych tests.

PROFILE: 0112-DUEH-91-002 - $1.50 ~ ARTICLES: 0112-DAVI-92-019 - $5.75 and 0112-DAVI-92-006 - $2.50

A PRACTICAL GUIDE FOR PHYSICIANS AND PATIENTS: IDENTIFYING AND CONTROLLING CHEMICAL EXPOSURES

This article by Grace Ziem, M.D., Dr. P.H., (co-chair for the MCS Task Force of the American Public Health Association) provides an excellent overview of the realities of MCS and the multitude of petrochemical exposures which most people are unaware that they experience daily through nearly every aspect of the typical lifestyle. Her published article is entitled "Multiple Chemical Sensitivity: Treatment and Follow-up: Avoidance and Control of Chemical Exposures."

PROFILE: 0112-DUEH-91-002a - $1.50 ~ ARTICLE: 0112-ZIEM-92-014 - $4.50

PESTICIDES AND REGULATION: THE MYTH OF SAFETY

A report by the California Senate Office of Research, provides a well documented list of pesticide hazards to humans, including those posed by inert ingredients and lack of safety testing.

PROFILE: 0002-DUEH-91-002 - $1.50 ~ ARTICLE: 0002-JENN-91-045 - $12.25

MULTIPLE CHEMICAL SENSITIVITY (MCS) AND THE BRAIN

There is actually more than one route by which substances can immediately affect, stimulate, or even directly enter the brain, such as via the olfactory apparatus in the nose. Claudia Miller, M.D., M.S., shows how chemically induced stimulation or damage to the limbic system of the brain could explain the myriad of symptoms in MCS. Her article is entitled "Possible Models for Multiple Chemical Sensitivity: Conceptual Issues and Role of Limbic System."

PROFILE: 0112-DUEH-92-002 - $1.50 ~ ARTICLE: 0112-MILL-92-022 - $6.50

PESTICIDE TREATMENTS IN THE WORKPLACE: EMPLOYEES AT RISK

This report investigates a pesticide poisoning incident at a casino and warns that employees chronically exposed to pesticides and the solvents in the formulations may be at risk for developing MCS. The study, by James Cone, M.D., M.P.H., and Thomas Sult, M.D., is "Acquired Intolerance to Solvents Following Acute Pesticide/Solvent Intoxication in a Building."

PROFILE: 0112-DUEH-92-002a - $1.50 ~ ARTICLE: 0112-CONE-92-011 - $3.75

CHEMICALS AND THE IMMUNE SYSTEM

William J. Meggs, M.D., Ph.D., provides a brief overview of MCS as it relates to the immune system and the inflammation and permanent tissue damage that can arise from chronic immune activation caused by chemical exposure in his article, "Multiple Chemical Sensitivities and the Immune System."

PROFILE: 0112-DUEH-92-002b - $1.50 ~ ARTICLE: 0112-MEGG-92-012 - $4.00

NATIONAL RESEARCH COUNCIL REPORT (NRC) ADDRESSES INDOOR AIR POLLUTION AND MCS

This 1992 NRC report presents evidence from the medical literature linking low level chemical exposure with adverse human health effects. Aba Terr's work is criticized for its lack of scientific merit and bias. Profile and article cover the chapter "Use of Biologic Markers in Controversial Areas of Environmental Health" and related portions and references from the NRC report "Biological Markers in Immunotoxicology."

PROFILE: 0112-DUEH-92-002c - $1.50 ~ ARTICLE: 0112-NRCB-92-023 - $6.75

DIAGNOSTIC TESTS FOR MULTIPLE CHEMICAL SENSITIVITY

Gunnar Heuser, M.D., Ph.D., F.A.C.P, of U.C.L.A. School of Medicine, et. al., list tests for diagnosing MCS and the degree of chemical injury in "Diagnostic Markers of Multiple Chemical Sensitivity." Presents test results for objective abnormalities in 135 MCS patients. Published in the National Research Council report "Multiple Chemical Sensitivities." A chart left out of that publication is included with the reprint provided through EARN courtesy of Dr. Heuser.

PROFILE: 0112-DUEH-92-002d - $1.50 ~ ARTICLE: 0112-HEUS-92-025 - $7.25

NRC REPORT ADDRESSES CHEMICALLY INDUCED AUTOIMMUNE DISEASE

This 1992 National Research Council report recognizes chemically-induced autoimmune disease, presents evidence, discusses diagnostic tests and predisposing factors. Profile and article cover chapter four, "Autoimmune Diseases," and related portions and references from the NRC report "Biologic Markers in Immunotoxicology."

PROFILE: 0071-DUEH-92-002 - $1.50 ~ ARTICLE: 0071-NRCB-92-021 - $6.25

SCREENING FOR NERVOUS SYSTEM DAMAGE FROM CHEMICAL EXPOSURE

This 1992 National Research Council report lists neurological and neuropsychological tests used to detect subtle chemical injury. The report warns about the lack of pre-market chemical testing and the dangers of chronic low-level exposure. Profile and article cover chapter five, "Surveillance to Prevent Neurotoxicity in Humans," and references from the NRC report "Environmental Neurotoxicology."

PROFILE: 0062-DUEH-92-002 - $1.50 ~ ARTICLE: 0062-NRCL-92-023 - $6.75

LEGAL RECOGNITION OF MCS BY US H.U.D.

This 1992 US Dept. of Housing and Urban Development policy memorandum "Multiple Chemical Sensitivity Disorder and Environmental Illness as Handicaps" presents legislative history and case precedents to back up their official recognition of MCS as a physiological handicap requiring accommodation on a case by case basis.

PROFILE: 0152-DUEH-92-002 - $1.50 ~ ARTICLE: 0152-HUDW-92-020 - $6.00

CHEMICAL POISONING, HOSPITAL PREPAREDNESS AND LIABILITY

This guide entitled "Don't Let This Happen to You: A Guide to Haz Mat Preparedness for Hospitals" by the District XI South Florida Local Emergency Planning Committee (LEPC) Hospital Preparedness Technical Advisory Committee was prepared to help hospitals and clinics recognize and treat chemical poisoning incidents in accordance with federal law. Includes checklists.

PROFILE: 0219-DUEH-92-002 - $1.50 ~ ARTICLE: 0219-LEPC-92-029 - $8.25

IMMUNOLOGICAL AND NEUROLOGICAL EFFECTS OF CHEMICALS ON THE RESPIRATORY TRACT: IMPLICATIONS FOR CHEMICAL SENSITIVITIES

This article by Rebecca Bascom, M.D., M.P.H., reviews some of the studies which have shown the effects of various chemicals on the respiratory tract. From the published proceedings of the AOEC 1991 MCS workshop.

PROFILE: 0112-DUEH-92-002e - $1.50 ~ ARTICLE: 0112-BASC-92-009 - $3.25

LEGAL STATUS OF MCS: PUBLIC ACCESS

"Measures Which Will Result in Greater Access for People with Environmental Illness/MCS to California's Publicly-Funded Facilities: Steps Toward Regulatory Remedies" by Susan Molloy, MA. Testimony before the CA Senate Committee on the Rights of Disabled Persons hearing on public access for people with MCS. Reports on accommodation cases.

PROFILE: 0112-DUEH-93-002 - $1.50 ~ ARTICLE: 0112-MOLL-92-034 - $9.50

PATIENTS' RIGHTS

Un-reviewed excerpts from the book Your Medical Rights: How to Become an Empowered Consumer by Charles Inlander of the People's Medical Society and Eugene Pavalon Esq. Includes forms to aid patients in keeping their own medical records.

PROFILE: 0219-DUEH-93-002 - $1.50 ~ ARTICLE: 0219-INLA-90-027 - $7.75

CLINICAL EVALUATION AND EXPOSURE CONTROL FOR CHEMICAL SENSITIVITY

A review of objective tests and evidence of organ system/tissue damage found in MCS patients. Presented by Grace Ziem, M.D., Dr. P.H., at the 1992 annual American Public Health Association meeting. Includes charts and forms for doctors to use in diagnosis and to aid their patients in workplace, school, and housing accommodation.

PROFILE: 0112-DUEH-93-002a - $1.50 ~ ARTICLE: 0112-ZIEM-92-018 - $5.50

CHEMICAL INJURY / CHEMICAL SENSITIVITY: OBJECTIVE TESTS AND FINDINGS

An invited editorial by Gunnar Heuser, M.D., M.P.H., F.A.C.P., published by J. Occ. Med. Toxicol. "Diagnostic Markers in Clinical Immunotoxicology and Neurotoxicology" lists objective tests for showing chemical injury and presents his current findings in sensitized patients.

PROFILE: 0112-DUEH-93-002b - $1.50 ~ ARTICLE: 0112-HEUS-92-006 - $2.50

CHEMICAL SENSITIVITY AND UPPER RESPIRATORY PROBLEMS

"Rhinolaryn-goscopic Examination of Patients with the Multiple Chemical Sensitivity Syndrome" by William J. Meggs, M.D., Ph.D., and Crawford H. Cleveland Jr., M.D., reports consistent upper-airway abnormalities.

PROFILE: 0112-DUEH-93-002c - $1.50 ~ ARTICLE: 0112-MEGG-93-005 - $2.25

IMMUNE ALTERATION ASSOCIATED WITH EXPOSURE TO TOXIC CHEMICALS

by Aristo Vojdani, Ph.D., Mamdooh Ghoneum, Ph.D., and Nachman Brautbar, M.D. Case-controlled study finding higher incidence of autoimmunity, chemical antibodies and immune activation or suppression in chemically exposed individuals. A personal communication (reported only in the Profile) quotes Vojdani who states that the patients in the study also had MCS.

PROFILE: 0070-DUEH-93-002 - $1.50 ~ ARTICLE: 0070-VOJD-92-016 - $5.00

BRAIN SCANS FOR CHEMICAL INJURY/CHEMICAL SENSITIVITY

Three-dimensional Brain Metabolic Imaging in Patients with Toxic Encephalopathy" by T.J. Callender, L. Morrow et al. Some tests are better than others for showing damage, SPECT is most consistent. Personal communications (reported only in the Profile) quote Dr. Callender who states the patients in the study were also sensitive to low levels of fumes and Dr. Heuser's finding of abnormal SPECT scans when patients were challenged with low perfume levels.

PROFILE: 0062-DUEH-93-002 - $1.50 ~ ARTICLE: 0062-CALL-93-025 - $7.25

THE HAZARDS OF CHEMICALS IN HOUSE DUST

"Chemical Contaminants in House Dust: Occurrences and Sources" by J.W. Roberts, W.T. Budd, J. Chuang, and R.G. Lewis (EPA). Review of the literature on pesticides, lead, and other chemical hazards in house dust. Presented at the International Conference on Indoor Air Quality and Climate 1993.

PROFILE: 0205-DUEH-93-002 - $1.50 ~ ARTICLE: 0205-ROBE-93-006 - $2.50

PESTICIDES AND HUMAN EXPOSURE

"Herbicides and Fungicides: A Perspective on Potential Human Exposure" by C.R. Clement and T. Colborn of the World Wildlife Fund, Washington D.C. Packed with disturbing statistics and cases demonstrating the problems associated with pesticide use, including insecticides.

PROFILE: 0002-DUEH-93-002 - $1.50 ~ ARTICLE: 0002-CLEM-92-018 - $5.50

IMPACT OF EXPOSURE TO MULTIPLE CONTAMINANTS ON SYMPTOMS OF SICK BUILDING SYNDROME

by Richard Menzies, M.D., M.Sc., (McGill University, Canada) et al. Double-blind study in four office buildings shows SBS may be related to a combination of contaminant exposures that may not pose a problem individually at low levels.

PROFILE: 0113-DUEH-93-002 - $1.50 ~ ARTICLE: 0113-MENZ-93-006 - $2.50

QEEG EVENT-RELATED POTENTIALS AND CHEMICAL INJURY

Study by Lisa A. Morrow, Ph.D., (Dept. of Psychiatry, Western Psychiatric Institute and Clinic, U. of Pittsburgh), and Stuart R. Steinhauer, Ph.D., (Director of Biometrics Research Program and Director of Clinical Psychophysiology at Veterans Affair Medical Center, Pittsburgh, and Research Assistant Professor of Psychiatry, U. of Pittsburgh), and Michael J. Hodgson, M.D., M.P.H., (Occupational and Environmental Program, U. of Pittsburgh). The authors discuss their research on solvent-exposed patients and state that P300 latency assessment is a "noninvasive objective measure" which "may serve as an empirical marker for CNS (central nervous system) impairment following neurotoxic exposure."

PROFILE: 0024-DUEH-94-002 - $1.50 ~ ARTICLE: 0024-MORR-92-006 - $2.50

COGNITIVE EVOKED POTENTIALS AND CHEMICAL SENSITIVITY

In this landmark study, neuroscientist Donald L. Dudley, M.D., President of the Washington Institute of Neuroscientists, found that 100% of the MCS patients had abnormal cognitive evoked potentials (also referred to event-related potentials) when challenge tested with low levels of various chemicals found in everyday life. #C25 includes Dudley's abstracts published in a peer-reviewed journal, and his back-up article submitted for publication.

PROFILE: 0112-DUEH-94-002 - $1.50 ~ ARTICLE: 0112-DUDL-94-024 - $7.00

EVIDENCE: THE NOSE PROVIDES DIRECT TRANSPORT OF CHEMICALS TO THE BRAIN

Set of three medical studies that show and explain how chemicals, including heavy metals and solvents, can be transported directly to the brain via the olfactory nerves.

PROFILE: 0098-DUEH-94-002 - $1.50 ARTICLES: 0098-HAST-91-008 - $3.00, 0098-PERL-87-001 - $1.25, and 0098-GHAN-90-006 - $2.50

ENVIRONMENTALLY RELATED DISORDERS OF THE NERVOUS SYSTEM

by Edward L. Baker M.D., M.P.H., Deputy Director of the National Institute for Occupational Safety and Health, Centers for Disease Control, et al. This article addresses what is known through classic toxicology and presents a concise overview of some of the basics of chemically induced nervous system damage.

PROFILE: 0062-DUEH-94-002 - $1.50 ~ ARTICLE: 0062-BAKE-90-021 - $6.25

P300 PROVIDES OBJECTIVE EVIDENCE OF CHEMICAL INJURY WHEN OTHER TESTS APPEAR NORMAL

This study by Heidi H. Wasch, Dept. of Neurology, U. of California, San Francisco, et al. provides further support for the use of cognitive evoked potentials (event-related potentials). They assess three patients exposed to hydrogen sulfide.

PROFILE: 0747-DUEH-94-002 - $1.50 ~ ARTICLE: 0747-WASC-89-003 - $1.75

HAZARD COMMUNICATIONS, MATERIAL SAFETY DATA SHEETS, AND THE LAW

This summary by Craig Beck, C.I.H., et al. discusses the legal right to know for employees and the responsibilities of employers.

PROFILE: 0151-DUEH-94-002 - $1.50 ~ ARTICLE: 0151-BECK-92-015 - $4.75

TOXIC ENCEPHALOPATHY vs. ALZHEIMER'S

"Prognosis in Chronic Toxic Encephalopathy: A Two-Year Follow-Up Study of 26 Housepainters with Occupational Encephalopathy" by P. Bruhn et al. of the Departments of Neurology and Neuroradiology, Rigshospitalet, Copenhagen, Denmark. Objective testing compares toxic encephalopathy with Alzheimer's and shows how to differentiate between the two.

PROFILE: 0062-DUEH-94-002a - $1.50 ~ ARTICLE: 0062-BRUH-81-014 - $4.50

TOXIC RESPONSES OF THE HEART AND VASCULAR SYSTEMS

By Joseph P. Hanig, Ph.D., and Eugene H. Herman, Ph.D. Provides an in-depth overview of how chemicals can affect the heart and vascular (blood vessels) systems.

PROFILE: 0056-DUEH-94-002 - $1.50 ~ ARTICLE: 0056-HANI-91-033 - $9.25

WHAT DO YOU GET WITH AN INDOOR AIR QUALITY INVESTIGATION?

"IAQ Investigations/Case Histories" by Robert W. Lea, P.E., Principal Materials Engineer for Law Engineering. This article outlines the basics of a typical IAQ investigation and reflects the minimum a person should require. Shortcomings and information left out of the article are addressed in the Profile.

PROFILE: 0205-DUEH-94-002 - $1.50 ~ ARTICLE: 0205-LEAR-94-013 - $4.25

INDEPENDENT DOUBLE-BLIND STUDY CONFIRMS CHEMICAL SENSITIVITY IN 1963

"Systemic Toxic Reactions to Soft Plastic Food Containers: A Double-Blind Study" by Eloise W. Kailin, M.D., and Clifton R. Brooks, M.D. This study shows that when true scientific principles and sound protocols are applied to testing MCS patients, their sensitivities can be verified by double-blind studies.

PROFILE: 0112-DUEH-94-002a - $1.50 ~ ARTICLE: 0112-KAIL-63-008 - $3.00

PSYCHOGENIC MCS STUDIES SERIOUSLY FLAWED

This critical review of the psychogenic MCS literature was published in a peer-reviewed medical journal. Drs. Ann L. Davidoff and Linda Fogarty of Johns Hopkins University detail the studies' deficiencies and outline the factors that should be taken into account when assessing the literature and studying MCS patients.

PROFILE: 0112-DUEH-94-002b - $1.50 ~ ARTICLE: 0112-DAVI-94-010 - $3.50

ELECTROMYOGRAPHIC EVIDENCE OF MUSCLE WEAKNESS IN DOUBLE-BLIND MCS CHALLENGE TESTING

Study by Eloise W. Kailin, M.D., and Alicia Hastings, M.D., provides objective evidence of reactions to low level pesticide exposure in MCS patients.

PROFILE: 0112-DUEH-95-002 - $1.50 ~ ARTICLE: 0112-KAIL-66-009 - $3.25

CEREBRAL DISTURBANCES IN MCS PATIENTS: A DOUBLE-BLIND PESTICIDE EXPOSURE STUDY

"Cerebral Disturbances from Small Amounts of DDT: A Con-trolled Study" by Eloise W. Kailin, M.D., and Alicia Hastings, M.D., confirms early evidence of MCS and includes observations on possible toxicologic mechanisms.

PROFILE: 0112-DUEH-95-002a - $1.50 ~ ARTICLE: 0112-KAIL-66-006 - $2.50

CHEMICALLY INDUCED RESPIRATORY CONDITIONS AND THEIR RELATIONSHIP TO MCS: A REVIEW

"RADS and RUDS - the Toxic Induction of Asthma and Rhinitis," by William J. Meggs, M.D., Ph.D., cites research showing increasing asthma incidence and death, and provides an overview of research regarding chemically induced respiratory conditions.

PROFILE: 0060-DUEH-95-002 - $1.50 ~ ARTICLE: 0060-MEGG-94-015 - $4.75

CHRONIC EXPOSURE: "EVALUATING HEALTH RISKS FROM OCCUPATIONAL EXPOSURE TO PESTICIDES AND THE REGULATORY RESPONSE"

Chronic health effects of pesticide exposure are of greater risk than acute effects according to this peer reviewed study based on research by the California EPA. The pesticide regulatory history and current problems are discussed along with recommendations for worker protection, in the absence of adequate regulations.

PROFILE: 0002-DUEH-95-002 - $1.50 ~ ARTICLE: 0002-WOOD-94-009 - $3.25

TIME-DEPENDENT SENSITIZATION (TDS) & MCS

Both of the studies presented in this profile present evidence from the published literature on TDS in animals that show the amazing parallels between the characteristics and symptoms of MCS in humans and TDS in an animal model. From the published proceedings of an Agency for Toxic Substances and Disease Registry conference.

PROFILE: 0112-DUEH-95-002b - $1.50 ARTICLES: 0112-SORG-94-018 - $5.50, and 0112-ANTE-94-008 - $3.00

INCREASED AIRWAY RESISTANCE IN MCS PATIENTS

Chemical inhalation challenge testing showed increased airway resistance in MCS patients as opposed to control subjects. From the published proceedings of the Agency for Toxic Substances and Disease Registry's conference on neurobiologic sensitivity.

PROFILE: 0112-DUEH-95-002c - $1.50 ~ ARTICLE: 0112-DOTY-94-010 - $3.50

INSTITUTE OF MEDICINE REPORT URGES DOCTORS AND MEDICAL SCHOOLS TO INCORPORATE ENVIRONMENTAL MEDICINE

"Executive Summary" and "Introduction" from this 1995 report summarizes the need for chemical hazards awareness and urges physicians to become more active in all aspects of the issue.

PROFILE: 0219-DUEH-95-002 - $1.50 ~ ARTICLE: 0219-IOMP-95-018 - $5.50

INSTITUTE OF MEDICINE REPORT LISTS SIX COMPETENCY-BASED OBJECTIVES FOR PHYSICIANS

"Chapter Two: Curriculum and Content" from this National Academy of Sciences' report discusses specifics of medical education reform.

PROFILE: 0219-DUEH-95-002a - $1.50 ~ ARTICLE: 0219-IOME-95-013 - $4.25

INSTITUTE OF MEDICINE ADDRESSES "FACULTY INERTIA" AND URGES INCORPORATION OF ENVIRONMENTAL MEDICINE

Chapter Four and the Concluding Remarks discuss problems with existing faculty and list recommendations.

PROFILE: 0219-DUEH-95-002b - $1.50 ~ ARTICLE: 0219-IOME-95-015 - $4.75

PORPHYRINOGENIC CHEMICALS & METABOLISM: MCS PATIENTS AT RISK

Review shows how numerous chemicals affect the heme biosynthetic pathway. The profile further defines biological consequences and discusses their relationship to chemical sensitivities.

PROFILE: 0077-DUEH-95-002 - $1.50 ~ ARTICLE: 0077-MARK-85-029 - $8.25

PORPHYRINOGENIC PESTICIDES: TOXIC TO ALL LIVING THINGS

Preface & Chapter One of Porphyric Pesticides by the American Chemical Society discusses how industry has been deliberately developing pesticides that disrupt the heme bio-synthetic pathway.

PROFILE: 0011-DUEH-95-002 - $1.50 ~ ARTICLE: 0011-DUKE-94-019 - $4.75

MCS STUDY COMPARING PESTICIDE AND REMODELING PATIENTS INDICATES NEUROLOGIC MECHANISM

Results of this study by Claudia Miller M.D. and Howard C. Mitzel M.D. indicate MCS is not a psychogenic somatoform disorder.

PROFILE: 0112-DUEH-96-002 - $1.50 ~ ARTICLE: 0112-MILL-95-011 - $3.75

CASE-CONTROLLED NEUROSPECT BRAIN SCAN STUDY SHOWS IMPAIRMENT IN CHEMICALLY EXPOSED PATIENTS

This study shows brain damage in solvent and pesticide-exposed individuals assessed by SPECT scan. A personal communication with Dr. Gunnar Heuser (reported only in the Profile) notes the majority of the patients in the study had multiple chemical sensitivities.

PROFILE: 0112-DUEH-96-002a - $1.50 ~ ARTICLE: 0112-HEUS-94-012 - $4.00

CHEMICAL SENSITIVITY AND TIME-DEPENDENT SENSITIZATION; SURVEYS SHOW POSSIBLE PREVALENCE IN THE GENERAL POPULATION

This study reports a high incidence of chemical and food sensitivities in older adults, compares the findings with other surveys that found high incidences of chemical odor intolerance, and ties them into time-dependent sensitization.

PROFILE: 0112-DUEH-96-002b - $1.50 ~ ARTICLE: 0112-BELL-93-013 - $4.25

CHEMICAL ODOR INTOLERANCE (CACOSMIA) IN COLLEGE STUDENTS IS CON-SISTENT WITH TIME-DEPENDENT SENSITIZATION

This study finds a high incidence of sensitivity to chemical odors in a survey of 800 college students. The researchers discuss how their results indicate a biologic mechanism rather than psychological, and tie it in to time-dependent sensitization.

PROFILE: 0066-DUEH-96-002 - $1.50 ~ ARTICLE: 0066-BELL-96-013 - $4.25

DETOX P450 ENZYMES AS THEY RELATE TO CHEMICAL SENSITIVITIES, INDIVIDUAL SUSCEPTIBILITY, PORPHYRINOPATHIES, AND TREATMENT: PART ONE

The study discusses nutritional and dietary factors impacting the ability of P450 enzymes to detoxify chemicals. The referenced profile gives additional background on the role of P450 enzymes, and shows how they relate to individual susceptibility and chemical sensitivities.

PROFILE: 0075-DUEH-96-002 - $1.50 ~ ARTICLE: 0075-GUEN-95-008 $3.00

DETOX P450 ENZYMES AS THEY RELATE TO CHEMICAL SENSITIVITIES, INDIVIDUAL SUSCEPTIBILITY, PORPHYRINOPATHIES, AND TREATMENT: PART TWO

This study discusses the role P450 enzymes play in chemically induced porphyria attacks.

PROFILE: 0077-DUEH-96-002 - $1.50 ~ ARTICLE: 0077-BICK-82-013 - $4.25

DETOX P450 ENZYMES AS THEY RELATE TO CHEMICAL SENSITIVITIES, INDIVIDUAL SUSCEPTIBILITY, PORPHYRINOPATHIES, AND TREATMENT: PART THREE

This profile discusses the paradoxes and difficulties involved in trying to treat MCS patients with disorders of porphyrin metabolism, as indicated by a number of studies reviewed by the profile. The ordering information for the individual studies is on the profile.

PROFILE: 0075-DUEH-96-004 - $2.00

RESPIRATORY INFLAMMATION AND OTHER ABNORMALITIES FOUND IN PATIENTS WITH CONCURRENT MCS, RUDS & RADS

This case-controlled study of MCS patients shows objective respiratory abnormalities supportive of neurogenic inflammation as a mechanism.

PROFILE: 0060-DUEH-97-002 - $1.50 ~ ARTICLE: 0060-MEGG-96-014 - $4.50

POLYSOMNOGRAPHIC TESTING SHOWS OBJECTIVE EVIDENCE OF SLEEP DISTURBANCES IN INDIVIDUALS WITH RELATIVELY MILD CHEMICAL ODOR INTOLERANCE

This biologic evidence is found in a case-controlled study.

PROFILE: 0112-DUEH-97-002 - $1.50 ~ ARTICLE: 0112-BELL-96-011 - $3.75

PREVALENCE STUDY FINDS WIDESPREAD CHEMICAL SENSITIVITIES IN GENERAL POPULATION

This study involving a survey of 1,027 adults found chemical sensitivities about as prevalent as asthma.

PROFILE: 0112-DUEH-97-002a - $1.50 ~ ARTICLE: 0012-MEGG-96-008 - $3.00

CHEMICAL SENSITIVITY AS AN EMERGING DISEASE MECHANISM

This review study by Claudia Miller, M.D., discusses evidence for MCS as a symptom, syndrome, or disease mechanism.

PROFILE: 0112-DUEH-97-002b - $1.50 ~ ARTICLE: 0112-MILL-96-018 - $4.40

RESEARCHERS PROPOSE AN ANIMAL MODEL FOR MCS CHOLINERGIC SUPERSENSITIVITY THAT ALSO ADDRESSES BIOLOGIC DEPRESSION

This study compares the numerous similarities between MCS symptoms and the characteristics of a strain of "supersensitive" rats.

PROFILE: 0112-DUEH-97-002c - $1.50 ~ ARTICLE: 0112-OVER-96-016 - $5.00

PHARMACEUTICALS MAY ACT SYNERGISTICALLY WITH PESTICIDES - SPECT SCANS CONFIRM CHRONIC POISONING SYMPTOMS

This study discusses how SPECT scans (and several other tests) can show chemical injuries and correlate with symptoms even when other tests (such as EEG and MRI) are normal.

#58 ~ PROFILE: 0062-DUEH-97-002 - $1.50 ~ ARTICLE: 0062-CALL-94-012 - $4.00

OBJECTIVE INJURIES IN GULF VETERANS ECHO MCS AND IMPLICATE CHEMICAL SYNERGY

This 4-page profile reviews the medical studies which show physiological injuries in Gulf Veterans and ties them in to findings about chemical sensitivity. The ordering information for individual studies is on the profile.

PROFILE: 0118-DUEH-97-004 - $2.00

VITAMIN C IMPROVES IMMUNE FUNCTION IN CHEMICALLY INJURED PATIENTS

This study by Dr. Heuser and Dr. Vojdani found that high doses of vitamin C restored some critical components of immune function in chemically injured individuals.

PROFILE: 0134-DUEH-97-002 - $1.50 ~ ARTICLE: 0134-HEUS-97-022 - $6.50

SBS OVERVIEW OBSERVES SOME MAY DEVELOP MCS

This study provides an overview of the characteristics of sick building syndrome, and notes that some individuals develop chronic MCS arising out of SBS exposure.

PROFILE: 0113-DUEH-98-002 - $1.50 ~ ARTICLE: 0113-REDL-97-004 - $2.00

OBJECTIVE EVIDENCE OF NEUROBIOLOGICAL PROCESSES IN ODOR INTOLERENT INDIVIDUALS

QEEG and SPECT testing, including challenge testing, confirms biologic injury in the brains of chemically sensitive patients in this study.

PROFILE: 0112-DUEH-98-002 - $1.50 ~ ARTICLE: 0112-CALL-95-009 - $3.25

MULTIPLE OBJECTIVE CLINICAL ABNORMALITIES IN MCS: PORPHYRIN, IMMUNE, AND NEUROLOGIC FINDINGS

Dr. Ziem's clinical research findings in over 300 MCS patients showing objective evidence of injury with objective testing are presented in this study.

PROFILE: 0112-DUEH-98-002a - $1.50 ~ ARTICLE: 0112-ZIEM-97-020 - $6.00

P300 PROVIDES OBJECTIVE ASSESSMENT OF COGNITIVE IMPAIRMENT FROM CHEMICALS

A study of solvent-exposed individuals with chronic toxic encephalopathy confirms the use of QEEG P300 testing to detect biological brain impairment.

PROFILE: 0024-DUEH-98-002 - $1.50 ~ ARTICLE: 0024-MORR-96-004 $2.00

AIR FRESHENER EMISSIONS CAUSE TOXIC HEALTH EFFECTS

This study shows respiratory and neurological effects of room air fresheners using the ASTM-E-981 rodent assay, a standardized test used to extrapolate results to humans.

PROFILE: 0205-DUEH-98-002 - $1.50 ~ ARTICLE: 0205-ANDE-97-009 $3.25

MCS, NEUROTOXICITY, AND RESPIRATORY TOXICITY FROM ORGANOPHOSPHATE PESTICIDES

This study reports the findings in 36 poisoning incidents, 14 of which resulted in MCS. Has an extensive overview of organophosphate health effects, and discussion of factors which result in chronic poisoning from indoor use of pesticides.

PROFILE: 0258-DUEH-98-002 - $1.50 ~ ARTICLE: 0258-SHER-95-007 - $2.75

GASOLINE FUME EXPOSURE CAUSES MCS IN LABORERS

This study showing MCS development in male tunnel workers exposed to gasoline fumes dispels numerous stereotypes about MCS.

PROFILE: 0112-DUEH-98-002b - $1.50 ~ ARTICLE: 0112-DAVI-98-007 - $2.75

CONTROLLED PERFUME STUDY REVEALS ADVERSE IRRITANT, RESPIRATORY, AND NEUROLOGIC EFFECTS

This study shows biological toxic effects of over-the-counter perfume products using the ASTM-E-981 rodent assay, a standardized test used to extrapolate results to humans.

PROFILE: 0216-DUEH-98-002 - $1.50 ~ ARTICLE: 0216-ANDE-97-009 $3.25

CARPET TOXICITY ASSOCIATED WITH MCS AND CHRONIC ILLNESS IN HUMANS

Study objectively confirms toxicity of carpet with animal testing corresponding to the symptoms in the human carpet owners.

PROFILE: 0228-DUEH-99-002 - $1.50 ~ ARTICLE: 0228-ANDE-97-009 - $3.25

CARDIAC AND RESPIRATORY DISEASE RISK FOUND IN EPIDEMIOLOGICAL STUDY OF CHEMICAL ODOR INTOLERANCE

This study finds chemically sensitive individuals have high incidence of cardiac and respiratory disease risk as compared to controls, indicating probable heritable risk factors may be involved in chemical intolerance.

PROFILE: 0066-DUEH-99-002 - $1.50 ~ ARTICLE: 0066-BALD-98-007 $2.75

EMF-LINKED NEUROVEGETATIVE, IMMUNOLOGIC, AND HEMATOLOGIC DISORDERS CONFIRMED IN HUMANS

Case control study with challenge re-exposures and animal confirmation testing provides evidence for EMF disorders.

PROFILE: 0120-DUEH-99-002 - $1.50 ~ ARTICLE: 0120-BONH-98-006 - $2.50

CHEMICALLY INDUCED REACTIVE INTESTINAL DYSFUNCTION SYNDROME (RIDS)

Case reports describe chemically induced RIDS in chemically sensitive patients.

PROFILE: 0121-DUEH-99-002 - $1.50 ~ ARTICLE: 0121-LIEB-98-004 - $2.00

MCS AND ITS RELATION TO CHEMICAL-INDUCED PORPHYRINOPATHY: PART ONE

Conference presentation by Dr. Morton describes over 100 cases of patients with MCS and chemically induced porphyrinopathy. Special charts are included to aid physicians in testing and diagnosis of lab abnormalities.

PROFILE: 0112-DUEH-99-004 - $2.00 ~ ARTICLE: 0112-MORT-98-014 - $4.50

MCS AND ITS RELATION TO CHEMICAL-INDUCED PORPHYRINOPATHY: PART TWO

In this second conference presentation, Dr. Morton further explains and addresses the issues and controversy of chemically induced porphyrinopathy in relation to MCS.

PROFILE: 0112-DUEH-99-004a - $2.00 ~ ARTICLE: 0112-MORT-98-008 - $3.00

MCS PATIENTS SHOW OBJECTIVE IMMUNE AND NEUROPSYCHIATRIC ABNORMALITIES IN A CHALLENGE EXPOSURE TEST

Objective testing confirms biological symptoms from low level exposure challenge test. Control subjects compared for one phase of the study.

PROFILE: 0112-DUEH-99-002 - $1.50 ~ ARTICLE: 0112-LITT-99-009 - $3.25

CHEMICAL SENSITIVITY AND CROSS SENSITIZATION TIME-DEPENDENT SENSITIZATION RESEARCH

This TDS animal research study lends strength to the brain limbic hypersensitization theory of MCS, and the profile ties the two together further and discusses possible neurochemical tie-ins with porphyrinopathy as revealed in additional research.

PROFILE: 0112-DUEH-99-004b - $2.00 ~ ARTICLE: 0112-SORG-98-010 - $3.50

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